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16-153: Evaluating the Efficacy of Atezolizumab in Advanced Non-small Cell Lung Cancer (NSCLC)

NCT03014648 | NCT03014648

Evaluating the Efficacy of Atezolizumab in Advanced Non-small Cell Lung Cancer (NSCLC)

Associated Conditions

Lung Cancer

Principal Investigator

Sponsor

University of Pittsburg Medical Center

Trial Type: Treatment.

This is a phase II clinical trial aimed at evaluating the efficacy of PD-L1 inhibition with atezolizumab in advanced squamous and non-squamous NSCLC patients previously treated with anti-PD-1 therapy with either nivolumab or pembrolizumab.
In order to account for the variability of response kinetics to PD-1 directed therapy, patients will be enrolled in 3 parallel cohorts based on the best overall response to PD-1 directed therapy.
     - Cohort 1 (progressive disease)
     - Cohort 2 (stable disease with minimum 12 weeks of therapy)
     - Cohort 3 (partial to complete response followed by progressive disease)

This study is currently enrolling.