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Associated Conditions

Cervical Cancer

Principal Investigator


Radiation Therapy Oncology Group (RTOG)

The purpose of this study is to compare the effects, good and/or bad, of giving additional chemotherapy to you after the usual treatment of chemotherapy and radiation for your cervical cancer. The routine treatment for your type of cervical cancer is cisplatin chemotherapy plus radiation. The study will determine whether adding chemotherapy with carboplatin and paclitaxel (experimental for your type of cervical cancer) to routine radiation and cisplatin chemotherapy improves survival without increasing side effects. Cisplatin, carboplatin, and paclitaxel are FDA (Food and Drug Administration) approved drugs used to treat a number of different types of cancer; however, carboplatin and paclitaxel are experimental for the treatment of cervical cancer. In this study, you will either receive radiation plus cisplatin alone or radiation plus cisplatin followed by carboplatin and paclitaxel. One of the routine treatment options for your stage and type of cervical cancer is external beam radiation therapy. Both three-dimensional radiation therapy and IMRT allow the radiation beam to treat an area that is shaped like your tumor and also to penetrate as deeply as your tumor is located. By treating this way, the dose of radiation to the healthy areas near your tumor is minimized, and the dose to your tumor is maximized. This study also will study biologic factors that may help to predict and treat cervical cancer. In addition, this study will gather information about the effects of radiation therapy and chemotherapy on your overall quality of life.

This study is currently enrolling.