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N/A ACME: The Influence of Glycemic Control and Obesity on Energy Balance and Metabolic Flexibility in Type 1 Diabetes

NCT03379792

ACME: The Influence of Glycemic Control and Obesity on Energy Balance and Metabolic Flexibility in Type 1 Diabetes

Principal Investigator

Sponsor

AdventHealth Orlando

You are invited to take part in a research study because you have a diagnosis of type 1 diabetes (T1D) for at least one year or meet the criteria for a non-diabetic matching control. There has been an alarming increase in the prevalence of obesity in type 1 diabetes (T1D) in recent years. Among young adults with T1D, recent studies have shown that 31% are overweight and 15% are obese. While some of the increase in obesity in patients with T1D is likely due to historical trends in diet and physical activity affecting the general population. Another probable cause could be the widespread adoption of intensive insulin therapy for the treatment of T1D. Therefore, there is an urgent need for specific, evidence-based recommendations for the prevention and management of obesity in T1D while also aimed at optimizing glucose control and weight status. To help the development of these recommendations, this study will address energy requirements in T1D and provide information about metabolism. This will most likely lead to successful control of blood glucose and weight (Phase I). In addition, this study will pilot a dietary intervention (Phase II) of a low carb, reduced calorie diet to promote weight loss and improve glycemic control for overweight T1D patients. If you are an overweight or obese T1D and have successfully completed Phase I, you might qualify for Phase II.