Translational Research Institute
Clinical Trials
SOUL - Semaglutide cardiovascular outcomes trial in patients with type 2 diabetes
We are doing this study to look at whether the study medicine (semaglutide) has a positive effect on heart disease in patients that have type 2 diabetes. This will be done by comparing the study medicine (semaglutide) against p ...
ABA: ABA-Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity
The purpose of this study is to determine the effects of oral abscisic acid (ABA) on glucose metabolism in subjects with defined prediabetes.
ACES: Ace Inhibitors Combined with Exercise for Hypertensive Seniors
The purpose of this research study is to see if regular exercise when combined with one of three commonly used high blood pressure medications can improve the physical abilities of older adults to perform their daily life activ ...
EPIC: Transcriptomic and epigenetic characterization of the subcutaneous fat depots in PCOS women
Polycystic ovary syndrome, or PCOS, is a hormonal condition where your reproductive hormones are out of balance. PCOS is also associated with an increased risk to become obese and a male-like fat tissue distribution in women (a ...
FIND-CKD: A randomized, double-blind, placebo-controlled, parallel-group, multicenter Phase 3 study to investigate the efficacy and safety of FInerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease.
Study Purpose: To determine the safety and efficacy of Finerenone along with standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease. To be enrolled in this study, you must m ...
GILEAD: A Phase 1, Randomized, Single-blind, Placebo-controlled, Multiple-dose, Two-sequence, Cross-over Study to Evaluate the Effect of Ranolazine on Glucagon Secretion in Subjects with Type 2 Diabetes Mellitus, Followed by An Open-label, Single-dose, Exenatide Active-control Period
The primary purpose of this study is to understand the reasons why Ranolazine may potentially treat patients with T2DM. Ranolazine has been shown to block glucagon and therefore results in a lowering of blood glucose levels. Th ...
GluCog: Glycemic Variability and Fluctuations in Cognitive Status in Adults with Type I Diabetes
The purposes of this study is to understand how thinking, emotions, and blood glucose fluctuate over hours and days in people with type I diabetes. Study Commitment: 1 Month Aged ≥ 18 years Sex: Male and Female Conditions/Eligi ...
MODIFY: A Case-Control, Observational, Proof of Mechanism Study to Define Microbiome-Mediated Gut Dysfunction Across the Spectrum of Non-Alcoholic Fatty Liver Disease.
This study is being done to understand if the bacteria that are in your colon (the gut microbiome) get into the cells of the intestinal wall in people with fatty liver or fibrosis compared to people with healthy livers. When th ...
NAD-flux: Measurement of NAD+ Synthesis in Human Skeletal Muscle
Nicotinamide adenine dinucleotide (NAD) is a vitally important substance that is found in all cells of the body. Elevated levels of NAD are linked to health and well-being. The key objective of this pilot research study is to ...