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George Simon, MD

George Simon, MD

Executive Medical Director



Dr. George R. Simon, MD, joins Moffitt Cancer Center and AdventHealth as Executive Medical Director of the joint Moffit Cancer Center-AdventHealth clinical research unit in Celebration. Dr. Simon brings more than 20 years of clinical oncology translational research experience to this new role. Most recently, he served as section chief of Translational Research in the Department of Thoracic/Head and Neck Medical Oncology at MD Anderson Cancer Center in Houston. Additionally, he served as medical director of the MD Anderson Cancer Network. He has also held director level positions at Hollings Cancer Center in Charleston, S.C., and Fox Chase Cancer Center in Philadelphia. Prior to that, Simon was a faculty member at Moffitt from 2000 to 2008 as director of Mesothelioma Research and a member of the Department of Thoracic Oncology. 

In addition to his role at AdventHealth Celebration, Simon will also be a senior member of the Chemical Biology and Molecular Medicine Program at Moffitt. He specializes in lung cancer, mesothelioma and thymoma. In particular, he studies optimal strategies to deliver personalized cancer care in the form of either immunotherapy or targeted therapy individualized to a patient’s tumor molecular profile. He has served as principal investigator on numerous clinical trials and received several federal grants to support his work.

Trained in Internal Medicine and Medical Oncology, Dr. Simon specializes in taking care of patients with lung cancer and other thoracic malignancies. Always acting in the patient’s best interest, Dr. Simon leans on his two decades of academic experience and clinical and translational research skills to develop patient-centered treatment recommendations that optimizes clinical benefit, Additionally, Dr. Simon also provides consultative services to community oncologist, trainees in medical oncology (Fellows) and faculty members in other institutions.