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George Simon, MD

George Simon, MD

Executive Medical Director, CRU Celebration

Cancer

Simon

Overview

Dr. George Simon joins Moffitt Cancer Center and AdventHealth as executive medical director of the joint Moffit Cancer Center-AdventHealth clinical research unit in Celebration. Dr. Simon brings more than 20 years of clinical oncology translational research experience to this new role. Most recently, he served as section chief of Translational Research in the Department of Thoracic/Head and Neck Medical Oncology at MD Anderson Cancer Center in Houston. Additionally, he served as medical director of the MD Anderson Cancer Network. He has also held director level positions at Hollings Cancer Center in Charleston, S.C., and Fox Chase Cancer Center in Philadelphia. Prior to that, Simon was a faculty member at Moffitt from 2000 to 2008 as director of Mesothelioma Research and a member of the Department of Thoracic Oncology. In addition to his role at AdventHealth Celebration, Simon will also be a senior member of the Chemical Biology and Molecular Medicine Program at Moffitt. He specializes in lung cancer, mesothelioma and thymoma. In particular, he studies optimal strategies to deliver personalized cancer care in the form of either immunotherapy or targeted therapy individualized to a patient’s tumor molecular profile. He has served as principal investigator on numerous clinical trials and received several federal grants to support his work.

Education & Training

Education

Christian Medical College, Punjab University

Residency

St. Joseph Hospital, Colorado

Fellowship

University if Colorado School of Medicine

Board Certifications

American Board of Hematology; American Board of Medical Oncology

Associated Clinical Trials

NCT03821935

A Phase 1 First-in Human, Multi-Center, Open Label Dose-Escalation Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination with ABBV-181 in Subjects with Locally Advanced or Metastatic Solid Tumors.

Icon for trial | M19-345 A Phase 1 First-in Human, Multi-Center, Open Label Dose-Escalation Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination with ABBV-181 in Subjects with Locally Advanced or Metastati

This study is currently enrolling.

The purpose of this study is to see if the study drug is safe and able to treat patients who have certain types of cancers, including solid tumors, triple negative breast cancer, pancreatic cancer, urothelial cancer, hepatocell ...

NCT3978689

A Phase 1, First-in-Human, Open-Label, Dose Escalation and Expansion Study of CUE-101 Monotherapy in Second Line and CUE-101 Combination Therapy with Pembrolizumab in First Line Patients with HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)

Icon for trial | CUE-101-01 A Phase 1, First-in-Human, Open-Label, Dose Escalation and Expansion Study of CUE-101 Monotherapy in Second Line and CUE-101 Combination Therapy with Pembrolizumab in First Line Patients with HPV16+ Recurrent/Metastatic Head and Neck Squamous C

Historically, patients with recurrent or metastatic head and neck cancer (HNSCC) have been treated with combinations of chemotherapeutic drugs. Recent studies with immunotherapy drugs that inhibit the programmed cell death 1 ( ...

NCT04669899

Phase 1 First-in-Human Study of Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) Inhibitor Monoclonal Antibody (mAb) JTX8064, as Monotherapy and in Combination with a Programmed Cell Death Receptor-1 (PD-1) Inhibitor, in Adult Subjects with Advanced Refractory Solid Tumor Malignancies

Icon for trial | JTX-8064-101 Phase 1 First-in-Human Study of Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) Inhibitor Monoclonal Antibody (mAb) JTX8064, as Monotherapy and in Combination with a Programmed Cell Death Receptor-1 (PD-1) Inhibitor, in Adult Subjects with

This study is currently enrolling.

A medical research study for participants who have been diagnosed with a solid tumor (i.e. cancer) and currently, the tumor is unresponsive to approved treatments, approved treatments are worsening the symptoms or the participa ...