Heart, Lung & Vascular Research Institute
Clinical Trials
A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of Sotatercept versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) due to Heart Failure with Preserved Ejection Fraction (HFpEF)
This study is currently enrolling.
You are being asked to take part in a research study of an experimental treatment called sotatercept. “Experimental” means that sotatercept is currently being tested and is not approved for sale by any Health Authorities/regula ...
A Phase 3 Study of Sotatercept in Participants with PAH WHO FC III or FC IV at High Risk of Mortality
This study is currently enrolling.
Pulmonary arterial hypertension (PAH) is a disease affecting the blood vessels of the lungs. PAH leads to increased pressure in the blood vessels of the lungs which further leads to straining of the right side of the heart. ...
Assessment of Implantable CCM in the Heart FaIlure Group with Higher Ejection FRaction
This study is currently enrolling.
Your doctor has diagnosed you with HF. You are being asked to consider voluntary participation in a research study of CCM treatment with the Optimizer System, sponsored by Impulse Dynamics (USA) Inc. CCM with the Optimizer Syst ...
BAROSTIM THERAPY in Heart Failure with Reduced Ejection Fraction A Post-Market Registry with the BAROSTIM NEO System
This study is currently enrolling.
You are invited to participate in a Registry to track the performance of the BAROSTIM NEO Device. You are being invited because you have been implanted with the Device because of your condition called heart failure. In this Reg ...
CATALYST - Clinical trial of atrial fibrillation patients comparing left atrial appendage occlusion therapy to non-vitamin K antagonist oral anticoagulants
This study is currently enrolling.
The purpose of this research study is to compare the safety and effectiveness of the Amulet device compared to non-vitamin K antagonist oral anticoagulants (NOACs) for ischemic stroke risk reduction. NOACs are a class or type ...
CLASP IID/IIF - A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter Mitral Valve Repair System compared to Abbott Mitraclip in patients with degenerative mitral regurgitation.
This study is currently enrolling.
The goal of this study is to assess the safety and performance of the PASCAL System in patients with symptomatic degenerative mitral regurgitation (DMR). Up to 300 participants will take part in this randomized study at up to 7 ...
DIAMOND AF II - DiamondTemp System for the Treatment of Persistent Atrial Fibrillation
This study is currently enrolling.
The purpose of this clinical study is to see whether a medical device called the DiamondTemp Ablation Catheter (also called the DiamondTemp Ablation System) can restore your heart to a normal heart rhythm.
DISCOVER US - AcQMap US Registry of Procedural and Long-term Clinical Outcomes
This study is currently enrolling.
The purpose of this registry is to collect additional data on the performance of the Acutus Medical, Inc. AcQMap System, as an imaging and mapping tool for ablations of complex arrhythmias. The device is a new type of diagnosti ...
ECLIPSE - Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting Eluting StEnts: The ECLIPSE Trial.
This study is currently enrolling.
The purpose of this trial is to evaluate orbital atherectomy vessel preparation compared to standard angioplasty prior to placing a stent for the treatment of CAD.