Translational Research Institute
Clinical Trials
AVAIL: AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry
This study is currently enrolling.
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease that leads to many health complications. Many people have this disease and do not know it. There are no medications available to treat it. The purpose of this ...
BATSR: BAT as a therapeutic for the metabolic and cardiac dysfunction with senescence
This study is currently enrolling.
To obtain a better understanding of how metabolic and heart health change with aging. To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if you meet the following criteria ...
CASINO: Low-Carbohydrate Diet and SGLT2-Inhibitor to Achieve Moderate Ketosis in Healthy Volunteers
This study is currently enrolling.
The purpose of this study is to test the hypothesis that a low-carbohydrate diet combined with an SGLT2-inhibitor is sufficient to induce moderate ketosis in healthy volunteers. To be enrolled in this study, you must meet certa ...
COMET: ImpaCt Of Shiftwork on METabolic Flexibility and Skeletal Muscle Clocks.
This study is currently enrolling.
Study Purpose: To determine how working a nighttime shift impacts your metabolism. To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if you meet the following criteria: Study ...
CT-868-004
A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of CT-868 Administered for 16 Weeks to Overweight and Obese Adult Participants with Type 1 Diabetes Mellitus
A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of CT-868 Administered for 16 Weeks to Overweight and Obese Adult Participants with Type 1 Diabetes Mellitus
This study is currently enrolling.
Study Purpose: To evaluate the safety and tolerability of the study drug, CT-868, and to study the effect that CT-868 has on Type 1 Diabetes and weight. To be enrolled in this study, you must meet certain requirements. You may ...
DREAM: Diabetes RElated to Acute pancreatitis and its Mechanisms (DREAM). An observational cohort study from the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC)
This study is currently enrolling.
Study Purpose: The purpose of this research study is to find out how many people with acute pancreatitis develop diabetes. Risk factors for diabetes and the types of diabetes that occur after acute pancreatitis will also be st ...
EX-BOOST: Exercise to boost response to checkpoint blockade immunotherapy
This study is currently enrolling.
Study Purpose: To obtain a better understanding on how exercise can improve outcomes for patients with skin cancers. To be enrolled in this study, you must meet certain requirements. You may be eligible to participate if you me ...
EXPET: Dynamic in vivo PET imaging and ex vivo biopsies from skeletal muscle and adipose tissue to investigate the effects of exercise on insulin resistance and mitochondrial energetics in type 2 diabetes
This study is currently enrolling.
The overall aim of this study is to investigate the effects of exercise training on skeletal muscle and adipose tissue insulin resistance in subjects with Type 2 Diabetes (T2D).
FABULINUS: A 52-week randomized, double-blind, placebo controlled, multi-center Phase 2b study with a 52-week blinded extension assessing safety and efficacy of frexalimab, a CD40L-antagonist monoclonal antibody, for preservation of pancreatic beta-cell function in adults and adolescents with newly diagnosed type 1 diabetes on insulin therapy.
This study is currently enrolling.
Study Purpose: The study is aimed to evaluate an investigational drug, frexalimab, for preservation of pancreatic beta cell function in adults and adolescents that have been newly diagnosed with Type 1 Diabetes and started on i ...