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Bret H. Goodpaster, PhD

Bret H. Goodpaster, PhD

Scientific Director at the Translational Research Institute

Translational Research

Bret H. Goodpaster

Overview

Bret Goodpaster, Ph.D. investigates the pathophysiology of human aging, obesity, insulin resistance, and diabetes, and the biological mechanisms underlying the health benefits of exercise.

Dr. Goodpaster has received a number of awards and honors for his work, including the Nathan Shock Award from the National Institute of Aging in 2008. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others? Which are the good fats and which are the bad fats?

Dr. Goodpaster has published >250 peer-reviewed papers, review articles and book chapters, has served on several Editorial Boards, and is currently an Associate Editor for Diabetologia. He has served on grant review panels for the NIH and the American Diabetes Association.

Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University. Prior to coming to the AdventHealth TRI-MD, he was Professor of Medicine and UPMC Chair for Diabetes and Metabolism Research at the University of Pittsburgh.

Articles

A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function

CIRCULATION

2021

Sedentary and Trained Older Men Have Distinct Circulating Exosomal microRNA Profiles at Baseline and in Response to Acute Exercise

FRONTIERS IN PHYSIOLOGY

2020

Exercise and Muscle Lipid Content, Composition, and Localization: Influence on Muscle Insulin Sensitivity

DIABETES

2020

Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle

SCIENTIFIC REPORTS

2020

Rebuttal from Bret H. Goodpaster

JOURNAL OF PHYSIOLOGY-LONDON

2020

Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging

FRONTIERS IN PHYSIOLOGY

2020

Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2020

Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults

FRONTIERS IN ENDOCRINOLOGY

2020

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles

AGING CELL

2020

Decreased Mitochondrial Dynamics Is Associated with Insulin Resistance, Metabolic Rate, and Fitness in African Americans

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

2020

Education & Training

Education

Ball State University, Muncie, IN

Fellowship

University of Pittsburgh, Pittsburgh, PA; Maastricht University in the Netherlands,

Associated Clinical Trials