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Bret H. Goodpaster, PhD

Bret H. Goodpaster, PhD

Scientific Director at the Translational Research Institute

Translational Research

Bret H. Goodpaster

Overview

Bret Goodpaster, Ph.D. investigates the pathophysiology of human aging, obesity, insulin resistance, and diabetes, and the biological mechanisms underlying the health benefits of exercise.

Dr. Goodpaster has received a number of awards and honors for his work, including the Nathan Shock Award from the National Institute of Aging in 2008. He is particularly well known for “the athlete’s paradox” which has shifted the paradigm in type 2 diabetes research to investigate, how and why does fat accumulation in muscle cause insulin resistance in some subjects but not others? Which are the good fats and which are the bad fats?

Dr. Goodpaster has published >250 peer-reviewed papers, review articles and book chapters, has served on several Editorial Boards, and is currently an Associate Editor for Diabetologia. He has served on grant review panels for the NIH and the American Diabetes Association.

Dr. Goodpaster obtained a B.S. in Biology from Purdue, and after completing a Pre-doctoral Fellowship at Maastricht University in the Netherlands, received his Ph.D. in Human Bioenergetics from Ball State University. Prior to coming to the AdventHealth TRI-MD, he was Professor of Medicine and UPMC Chair for Diabetes and Metabolism Research at the University of Pittsburgh.

Articles

Sedentary and Trained Older Men Have Distinct Circulating Exosomal microRNA Profiles at Baseline and in Response to Acute Exercise

FRONTIERS IN PHYSIOLOGY

2020

Exercise and Muscle Lipid Content, Composition, and Localization: Influence on Muscle Insulin Sensitivity

DIABETES

2020

Decreased Mitochondrial Dynamics Is Associated with Insulin Resistance, Metabolic Rate, and Fitness in African Americans

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

2020

Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

2019

Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes

PHYSIOLOGICAL GENOMICS

2019

Plasma lactate as a marker of metabolic health: Implications of elevated lactate for impairment of aerobic metabolism in the metabolic syndrome

SURGERY

2019

Precision exercise medicine: understanding exercise response variability

BRITISH JOURNAL OF SPORTS MEDICINE

2019

Calorie Restriction-induced Weight Loss and Exercise Have Differential Effects on Skeletal Muscle Mitochondria Despite Similar Effects on Insulin Sensitivity

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2018

Effects of Exercise and Aging on Skeletal Muscle

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE

2018

Mitochondrial Respiration is Associated with Lower Energy Expenditure and Lower Aerobic Capacity in African American Women

Obesity

2018

Education & Training

Education

Ball State University, Muncie, IN

Fellowship

University of Pittsburgh, Pittsburgh, PA; Maastricht University in the Netherlands,

Associated Clinical Trials

NCT03960827

Molecular Transducers of Physical Activity Consortium (MoTrPAC)

Icon for trial | Molecular Transducers of Physical Activity Consortium (MoTrPAC)

This study is currently enrolling.

The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, a mechanistic randomized controlled trial (RC ...