The purpose of this research study is to assess the safety and efficacy of apixaban (which is an anti-clotting drug) in the treatment of blood clots in the upper leg (deep vein thrombosis) and/or lung (pulmonary embolism) or an ...

The purpose of this research is to learn more about the possible causes of Wilms tumor and the effects of successful treatment for Wilms tumor. You have been asked to participate in this voluntary study because you had a Wilms ...

The overall goal of this study is to learn about the neuropsychological (for example, thinking, learning, and remembering) and behavioral functioning of children being treated for cancer. Another goal of this study is to find o ...

We want to find better ways to detect tumors early. We would also like to find ways to prevent the tumors from starting. To do this, we need more information about childhood tumors. Some research looks at diseases that are pass ...

This study is being done to find out: If treatment based on each subject's level of risk will get rid of the tumor and if lessening the treatment for lower risk subjects will decrease the side effects of treatment and still ge ...

The overall goal of this study is to compare the effects, good and/or bad, of the chemotherapy drugs carboplatin and isotretinoin on subjects with high risk medulloblastoma and to find out if one or both are better than standar ...

The overall goal for all subjects in this study is: Based on group assignment, we want to see if we can treat non-high-risk NBL by either not doing surgery or by changing the amount of chemotherapy given and still get very good ...

You are being asked to take part in this study because you have neuroblastoma. We would like to collect samples of your tumor, blood and/or bone marrow to learn more about neuroblastoma. We are asking your permission to use som ...

The main goals of this study are: To compare laboratory tests and other evaluations associated with risk of heart failure between subjects selected by chance (randomization) to take low-dose carvedilol or placebo for 2 years. ( ...

The main goals of this study are: To look at potential effects on fertility in male osteosarcoma survivors treated with cisplatin with or without ifosfamide compared to male controls without a history of cancer. To learn whethe ...

The main purpose of this study is to learn how well tumors that have specific genetic changes (mutations) respond to drugs that target those changes. This combination of a tumor with a mutation and a drug that aims at that muta ...

We are doing this study to find better ways to diagnose, treat and prevent cancers in children, adolescents and young adults. To do this, we need to learn more about cancers that happen to children, adolescents and young adults ...

The overall goals of this study are to: To find out if subjects with standard risk DS AML can be treated with less treatment and still have successful outcomes. To find out if subjects with high risk DS AML can be successfully ...

The overall goals of this study are to: Find out what effects, good and/or bad, XL184 has on your tumor or type of cancer; to learn more about the side effects of XL184; to learn more about how XL184 works against cancer cells ...

Over the past years, many studies have been done for children with kidney tumors. Each study done has increased what we know about these tumors and has helped doctors plan treatment for subjects with these tumors. Researchers n ...

The overall goal of this study is to keep in contact with participants of COG clinical trials, so that up-to-date information will be available about these participants as they get older. This includes current name, contact, an ...

This research is conducted to study an investigational drug referred to as PD-0325901 (also known as mirdametinib) that has not been approved by the US Food and Drug Administration (FDA) or any other Regulatory Authority for th ...

The major goal of Induction therapy is to use a combination of chemotherapy drugs to try to eliminate as many of the leukemia cells as possible. We will also collect information from you that may be used to help further define ...

The overall goal of Part I of this study is to collect information about your leukemia and your response to the first phase of treatment, called Induction. Part I of the study is necessary to determine if you will be eligible f ...

The overall goals of this study are to: Compare the effects, good and/or bad, of the experimental drug 131I-MIBG added to current COG recommended therapy to the effects of current COG recommended therapy without the experimenta ...

Low Risk Subjects (Age <50 Years): The overall goal is to see if monitoring subjects with low risk germ cell tumors after their tumor is removed is as effective as following surgery with chemotherapy and/or more surgery. Sta ...

The overall goals of this study are to: (1) Learn how the treatment for high-risk neuroblastoma affects your long term health; (2) Learn if treatment for high-risk neuroblastoma affects how we learn and remember, solve problems ...

The overall goal of this study is to find out what effect, good and/or bad, the drug inotuzumab ozogamicin has on children and young adults with relapsed or refractory B-ALL.

The overall goal of this study is to find out if a reduced dose of radiation to the whole brain and spine and less chemotherapy can be given to children and young adults with WNT subtype medulloblastoma without increasing the r ...

Subjects in Part 1 (Dose Finding Phase) Only: The overall goals of this study are: (1) to compare the effects, good and/or bad, of a new combination of chemotherapy using VAC/VI plus temsirolimus; (2) to find if adding the drug ...

Disseminated B-Cell Lymphoblastic Lymphoma (B-LLy): The overall goal of this study is to determine the outcomes of subjects with disseminated B-LLy receiving High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL) therapy. Mix ...

When patients become allergic to PEG-asparaginase, they may receive another form of asparaginase called RC-P. This asparaginase preparation is not yet approved by the FDA and is considered experimental. RC-P is investigational ...

The overall goal of this study is to test any good and bad effects of the study drug LOXO-101 (larotrectinib) on your tumor.

The goals of this study are: (a) the main goal is to test any good and bad effects of the study drug JNJ-42756493 (erdafitinib) on your tumor; (b) a second goal of this study is to evaluate side effects that might be caused by ...

The overall goal of this study is to test any good and bad effects of the study drug tazemetostat on your tumor.

This is a Phase 2 study of a drug called LY3023414. In a Phase 2 study, the goal is to find out what effects, good and/or bad, a drug has on your tumor or type of cancer.

The main goal is to test any good and bad effects of the study drug selumetinib (AZD6244 hydrogen sulfate) on your tumor. A second goal of the study is to evaluate side effects that might be caused by selumetinib (AZD6244 hydro ...

You are being asked to participate in this study because you have a relapsed or refractory tumor without a proven treatment strategy for cure. The main goal of this study is to test any good and bad effects of the ensartinib on ...

You are being asked to participate in this study because you have relapsed or refractory tumor without a proven treatment strategy for cure. The main goal is to test any good and bad effects of the study drug vemurafenib on you ...

The main goal is to test any good and bad effects of the study drug olaparib on your tumor. A second goal of the study is to evaluate side effects that might be caused by olaparib and to learn more about the pharmacology (how y ...

The main goal of this study is to test any good and bad effects of the palbociclib on your tumor. A second goal of the study is to evaluate side effects that might be caused by palbociclib.

You are being asked to take part in this research study because your tumor results from the NCI-COG Pediatric MATCH screening protocol make you a candidate to receive the study drug called BVD-523FB (ulixertinib) that we are te ...

The overall goal of this study is to see if veliparib given with radiation therapy followed by veliparib with temozolomide given as maintenance therapy works better than treatments that have been tried in the past.

The overall goal of this study are to: Part 1 - Find the best dose of ruxolitinib to use with standard chemotherapy in children, adolescents, and young adults with HR B-ALL; Part 2 - Find out if the investigational drug ruxolit ...

The study doctors want to see if using dabrafenib and trametinib after radiation treatment will be better than treatments used in the past in helping to get rid of or shrink HGGs. Dabrafenib works by blocking protein (a basic ...

The overall goals of this study are to see if selumetinib works just as well as the standard treatment of carboplatin/vincristine (CV) for subjects with NF1-associated LGG, and to see if selumetinib is better than CV in improvi ...

The main goal is to find out what effect, good and/or bad effects AG-120 (ivosidenib) on your tumor. A second goal of the study is to evaluate side effects that might be caused by AG-120 (ivosidenib), which could shrink your ca ...

This is a Phase 2 study of a study drug called tipifarnib. The main goal of the study is to find out what effect, good and/or bad effects the study drug tipifarnib may have on your tumor. A second goal of the study is to evalua ...

This study looks at how well a drug called selumetinib works when given to children and young adults with LGG. The study doctors want to see if selumetinib works as well as CV for getting rid of or shrinking LGGs and stopping t ...

The overall goal of this study is to compare the effects, good and/or bad, of CPX-351 with daunorubicin and cytarabine on people with newly diagnosed AML to find out which is better. This study will compare standard chemotherap ...

Because hepatoblastomas are rare tumors, it has been difficult to progress research in this area. However, in this study, Children's Oncology Group will partner with other research groups in Europe and Japan to combine ef ...

This is a Phase 2 study of a drug called LOXO-292. In a Phase 2 study, the goal is to find out what effects, good and/or bad, a drug has on your tumor or type of cancer. LOXO-292 is experimental because it has not been proven t ...

The overall goals of this study are: (1) To compare the effect of 2 different physical activity programs on physical activity levels in adolescents and young adults who received and completed treatment for cancer; and (2) To me ...

A study to compare blinatumomab alone to blinatumomab with nivolumab in patients diagnosed with first relapse B-cell Acute Lymphoblastic Leukemia (B-ALL)