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Paul M. Coen, PhD

Paul M. Coen, PhD

Associate Investigator at the Translational Research Institute

Translational Research

Paul M. Coen

Overview

Dr. Paul Coen is an Associate Investigator at the Translational Research Institute for Metabolism and Diabetes, AdventHealth Orlando.

Paul’s research program is supported by the National Institutes of Health (NIH) and is broadly focused on elucidating the role of skeletal muscle mitochondrial energetics in the pathophysiology’s associated with aging and obesity.
Paul’s postdoctoral training was in the area of muscle metabolism under the mentorship of Dr. Bret Goodpaster at the University of Pittsburgh’s Division of Endocrinology and Metabolism (2008-2010). His postdoctoral work resulted in authorship on numerous peer-reviewed publications in high impact journals such as the Journal of Clinical Investigation, Diabetes, and Diabetes Care.

Originally hailing from Dublin, Ireland, Paul made the jump across the pond to study for a PhD in Exercise Physiology at Purdue University, which he completed in 2008. Prior to this, he completed an M.S. in Vascular Biology at the Vascular Health Research Center (VHRC) at Dublin City University (2004), and received his initial didactic and laboratory-based training with a B.Sc. in Bioanalytical Science from the Institute of Technology, Tallaght, Ireland (2000).

Articles

Sedentary and Trained Older Men Have Distinct Circulating Exosomal microRNA Profiles at Baseline and in Response to Acute Exercise

FRONTIERS IN PHYSIOLOGY

2020

Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes

PHYSIOLOGICAL GENOMICS

2019

Plasma lactate as a marker of metabolic health: Implications of elevated lactate for impairment of aerobic metabolism in the metabolic syndrome

SURGERY

2019

Mitochondria as a Target for Mitigating Sarcopenia

FRONTIERS IN PHYSIOLOGY

2019

Metabolomics Analyses of Muscle Atrophy Induced by Hind Limb Unloading

METABOLOMICS: METHODS AND PROTOCOLS

2019

Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

2019

Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging

AGING CELL

2018

Calorie Restriction-induced Weight Loss and Exercise Have Differential Effects on Skeletal Muscle Mitochondria Despite Similar Effects on Insulin Sensitivity

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

2018

Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

2018

Exercise and Bariatric Surgery: An Effective Therapeutic Strategy

EXERCISE AND SPORT SCIENCES REVIEWS

2018

Education & Training

Education

Purdue University, West Lafayette, IN

Fellowship

University of Pittsburgh School of Medicine

Associated Clinical Trials