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Steven R. Smith, MD

Steven R. Smith, MD

Chief Scientific Officer, Senior Vice President of the AdventHealth Research Institute

Translational Research, Infectious Disease

S. Smith

Overview

Dr. Steven R. Smith is Senior Vice President and Chief Scientific Officer of AdventHealth Research Institute guiding the research vision for AdventHealth. Smith also serves as the Associate Center Director, AdventHealth – Moffit Cancer Center Partnership. Smith’s scientific work within the TRI bridges the gap between cell/molecular biology and clinical care. Translational science involves translating discoveries in the basic sciences to the clinic and importantly informing basic science with clinical phenotyping and biospecimens.

Dr. Smith’s research is focused on obesity, diabetes and the metabolic origins of cardiovascular disease. He is specifically focused on how individuals differ in their ability to adapt to diets high in fat and understanding how obesity leads to type 2 diabetes. Using the translational medicine approach, Dr. Smith discovered that many obese people have an inability to burn fat and a new hormonal control system to increase fat and energy metabolism. Most importantly, the discovery that the inability to burn fat is programmed into muscle cells provides a novel way to identify and test new treatments for obesity and diabetes.

In the clinic, Dr. Smith has a special interest in the identification and development of drugs for the treatment of obesity and diabetes. His translational work demonstrated that each person is unique at the molecular level suggesting new ways to match therapies to the individual; this is the goal of field ‘personalized medicine.’

Articles

Physiology of Energy Expenditure in the Weight-Reduced State

Obesity

2021

A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function

CIRCULATION

2021

Energy intake as a short-term biomarker for weight loss in adults with obesity receiving liraglutide: A randomized trial

OBESITY SCIENCE & PRACTICE

2021

Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS

2020

Fat Distribution in Women Is Associated With Depot-Specific Transcriptomic Signatures and Chromatin Structure

JOURNAL OF THE ENDOCRINE SOCIETY

2020

An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression

PHYSIOLOGICAL REPORTS

2020

Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women

FRONTIERS IN PHYSIOLOGY

2020

Boosting NAD(+) with a small molecule that activates NAMPT

NATURE COMMUNICATIONS

2019

Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial

CIRCULATION

2019

Objectively measured pediatric obesity prevalence using the OneFlorida Clinical Research Consortium

OBESITY RESEARCH & CLINICAL PRACTICE

2019

Education & Training

Education

University of Texas Health Science Center, San Antonio, TX

Residency

Baylor University Medical Center, Dallas, TX

Fellowship

Ochsner Clinic and Hospital, New Orleans, LA

Specialty

Obesity & Diabetes

Associated Clinical Trials

COVID-19

Icon for trial | COVID-19 Research

At AdventHealth our goal is to continue fighting COVID-19 until it is a thing of the past. Ongoing clinical trials and research studies help by contributing knowledge to the fight against COVID-19. 

NCT02226640

Uncovering the ORIGIN’ of diabetes

Icon for trial | Uncovering the ORIGIN’ of diabetes

The purpose of this study is to collect data to help researchers better understand the various causes of Type 2 Diabetes Mellitus (T2DM). This information may lead to T2DM treatment options that are more tailored to an individ ...

Effects of Glucagon Administration on Energy Expenditure

Icon for trial | Effects of Glucagon Administration on Energy Expenditure

The purpose of this study is to collect data to help researchers better understand the effects of glucagon on the amount of calories you burn. This will provide important information on the development of new forms of treatment ...