NCT04639050

: BP42155: A Phase Ib/IIa, Randomized, Double Blind, Placebo-Controlled, Multiple Ascending Dose, Parallel-Group Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Patients With Prodromal or Mild to Moderate Alzheimer's Disease (Brainshuttle AD)

Icon for trial | BP42155 : BP42155: A Phase Ib/IIa, Randomized, Double Blind, Placebo-Controlled, Multiple Ascending Dose, Parallel-Group Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in P

This study is currently enrolling.

Trontinemab is an experimental drug that is being developed for the possible treatment of AD. Trontinemab combines an anti-amyloid antibody with a brain shuttle module which helps to deliver the antibody to the brain. It works ...

NCT05654922

A Phase 3, Open-Label, Randomized, Standard of Care- Controlled, Parallel Arm Study to Demonstrate Efficacy and Safety of ARINA-1 in the Prevention of Bronchiolitis Obliterans Syndrome Progression in Participants with Bilateral Lung Transplant

Icon for trial | RVN-001 A Phase 3, Open-Label, Randomized, Standard of Care- Controlled, Parallel Arm Study to Demonstrate Efficacy and Safety of ARINA-1 in the Prevention of Bronchiolitis Obliterans Syndrome Progression in Participants with Bilateral Lung Transplant

This study is currently enrolling.

The purpose of this research study is to see if the investigational drug, ARINA-1 when used with the investigational PARI eFlow nebulizer system, can stabilize or improve the lung function of participants who have had a bilater ...

NCT05702034

A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack

Icon for trial | 70033093STR3001 A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention after an Acute Ischemic Stroke or High-Risk Transient Is

This study is currently enrolling.

The purpose of this study is to see if an experimental drug, called Milvexian in addition to standard of care, is safe and useful in reducing the risk of future ischemic stroke in subjects after ischemic stroke or transient isc ...

NCT04419779

REVITALIZE-1: A Prospective randomized, double-blind, sham-controlled, multi-center pivotal study to evaluate the efficacy and safety of Duodenal Mucosal Resurfacing (DMR) using the Revita system in subjects with type 2 diabetes on insulin therapy.

Icon for trial | C-00044 REVITALIZE-1: A Prospective randomized, double-blind, sham-controlled, multi-center pivotal study to evaluate the efficacy and safety of Duodenal Mucosal Resurfacing (DMR) using the Revita system in subjects with type 2 diabetes on insulin therapy

This study is currently enrolling.

Study Purpose: The purpose of this study is to demonstrate the efficacy and safety of the Fractyl DMR Procedure using the Revita System compared to a sham. To be enrolled in this study, you must meet certain requirements. You m ...

NCT06026410

KO-2806-001: Phase 1, First-in-Human, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of KO-2806 When Administered as Monotherapy and in Combination Therapy in Adult Patients with Advanced Solid Tumors

Icon for trial | KO-2806-001 KO-2806-001: Phase 1, First-in-Human, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of KO-2806 When Administered as Monotherapy and in Combination The

This study is currently enrolling.

The purposes of this study are to: • Determine the highest tolerable dose of KO-2806 given orally (by mouth) in combination with cabozantinib. • Determine whether KO-2806 has an antitumor effect (reduces the size of your tumor ...

NCT06191796

XL092-009 A Phase 1b/2 Dose-Finding And Expansion Study Evaluating The Safety And Efficacy Of Xl092 Combined With Either AB521 OR AB521 Plus Nivolumab In Subjects With Advanced Clear Cell Renal Cell Carcinoma Or Other Advanced Solid Tumors

Icon for trial | XL092-009 XL092-009 A Phase 1b/2 Dose-Finding And Expansion Study Evaluating The Safety And Efficacy Of Xl092 Combined With Either AB521 OR AB521 Plus Nivolumab In Subjects With Advanced Clear Cell Renal Cell Carcinoma Or Other Advanced Solid Tumors

This study is currently enrolling.

To determine the recommended doses (RDs) of zanzalintinib and AB521 when administered in combination (doublet) in subjects with advanced solid tumors, and in combination plus nivolumab (triplet) in subjects with advanced ccRCC ...

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